Keppra

Keppra (Levetiracetam)

Uses:

• Commonly used to treat
  • seizure

Advantage of this medication:

• No major side effect
• Available by oral and injection form
• Cost: generic available, covered by most insurance
  • Based on GoodRx: cash price
  • 500 mg: 60 tab about $10

Dosing

• Most commonly used forms: 500, 1000 mg tablet
• Usually taken twice a day
• Kidney disease:
  • Mild kidney disease: no change in dose is needed
  • CrCl less than 30: use a lower dose, such as 500 mg twice a day
  • CrCl less than 15: up to 500 mg once a day
  • Hemodialysis patients: dialyzable 50%. 500 to 1000 mg after dialysis.

Side effects:

• Over 10%
  • increased blood pressure
  • behavioral problem
  • infection
  • weakness
  • nasopharyngitis